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Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Your doctor will do laboratory tests to monitor your response. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Before using, check this product visually for particles or discoloration. 1. Minor/Significance Unknown. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Ferritin and transferrin are also recommended monitoring . Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Applies only to oral form of both agents. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Use Caution/Monitor. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: vitamin products, other iron-containing products. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Applies only to oral form of both agents. Venofer (iron sucrose) Uses, Dosage, Side Effects - Drugs.com Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. No data are available regarding overdosage of Venofer in humans. Applies only to oral form of both agents. If we don't have the calculator you need then tell us the details and we'll make it for you. Use Caution/Monitor. 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Use Caution/Monitor. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Monitor Closely (1)trientine, iron sucrose. Avoid or Use Alternate Drug. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Applies only to oral form of both agents. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. One dose IV Iron replacement | Monoferric Venofer / Products / American Regent Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. Most The elemental iron product used is Iron sucrose 20 mg/mL. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Each mL contains 20 mg of elemental iron. Venofer has not been studied in patients younger than 2 years old. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Use Caution/Monitor. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Applies only to oral form of both agents. Separate by 2 hr. Volume of iron product required = 25 mL. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Minor/Significance Unknown. Intravenous iron sucrose for children with iron deficiency failing to 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. For additional Safety Information, please see Full Prescribing Information. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Use Caution/Monitor. Avoid or Use Alternate Drug. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Avoid or Use Alternate Drug. Schweiz Med Wochenschr; 100(7):301-3. 1974 Jun;31(6):592-5. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Minor/Significance Unknown. STORAGE: Consult the product instructions and your pharmacist for storage details. Available for Android and iOS devices. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Fatal reactions have followed the test dose of iron dextran injection. Minor/Significance Unknown. Either increases effects of the other by pharmacodynamic synergism. Intravenous iron-dextran: therapeutic and experimental possibilities. Perinatology and Obstetrical Calculators Information last revised December 2022. There is in depth information below the form on the method used and on the result provided. Applies only to oral form of both agents. Avoid or Use Alternate Drug. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Parenteral iron dextran therapy: a review. This calculator will help pinpoint potential causes of anemia based on Avoid or Use Alternate Drug. Accessed: 4/12/2011. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Many patients with kidney disease cannot get enough iron from food and require injections. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Avoid or Use Alternate Drug. Use Caution/Monitor. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. 2000 Jan;22(1):39-43. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Administer while the patient is in a reclined or semi-reclined position. 1995 Mar-Apr;11(2):163-8. Iron Product. Separate dosing of tetracyclines from these products. Schrier SL, Mentzer WC, Landaw SA. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Use Caution/Monitor. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Venofer (iron sucrose) dose calculator | Calculosaurus.com iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. This information does not assure that this product is safe, effective, or appropriate for you. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. official version of the modified score here. Modify Therapy/Monitor Closely. Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. 1. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Adding plans allows you to compare formulary status to other drugs in the same class. Applies only to oral form of both agents. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Avoid or Use Alternate Drug. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Minor/Significance Unknown. Applies only to oral form of both agents. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. When iron sucrose was administered at deliberate overdoses to rabbit dams (up to 215 mg/kg/day) marked fetal/placental iron overload was noted. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. 2010;18(3). UpToDate. https://www.uptodate.com/ (Requires subscription). Contact the applicable plan Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. J Med. Avoid or Use Alternate Drug. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Medicinal forms (3) Known hypersensitivity to Venofer. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. Do Not Copy, Distribute or otherwise Disseminate without express permission. UpToDate. Each mL contains 20 mg of elemental iron. This drug is available at a middle level co-pay. Our dosage calculator can help you with this as well. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. A healthcare provider will give you this injection. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. If you log out, you will be required to enter your username and password the next time you visit. Uses for Iron Sucrose Your doctor will do laboratory tests to monitor your response. Schweiz Med Wochenschr. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Applies only to oral form of both agents. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Kidney Int. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. Contraindicated. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The recipient will receive more details and instructions to access this offer. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. IDA diagnosis is based on full blood examination and on the serum ferritin level. Use Caution/Monitor. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Use Caution/Monitor. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) Applies only to oral form of both agents. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. Avoid or Use Alternate Drug. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . Use Caution/Monitor. Diagnosis and management of iron deficiency anaemia: a clinical update. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Consult your doctor before breast-feeding. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. The dosage of Venofer is expressed in mg of elemental iron. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Administer on 5 different occasions over a 14 day period. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer treatment may be repeated if necessary. This topic . IV iron sucrose (Venofer) given as divided dosages, and low molecular weight iron dextran (CosmoFer) this can be given as divided dose or as a total dose infusion . Use Caution/Monitor. Dosage Calculator - [100% Free] - Calculators.io Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Comparable efficacy to that of IV iron sucrose. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Treatment of anemia due to iron deficiency. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. This may be helped by giving the medication more slowly or at a lower dose. All Rights Reserved. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. iron sucrose, benazepril. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Burns DL, Mascioli EA, Bistrian BR. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Minor/Significance Unknown. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. No additional iron to replenish stores. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Slowing the infusion rate may alleviate symptoms. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. The dosage of Venofer is expressed in mg of elemental iron. May increase risk of hypotension. Am J Hosp Pharm. Iron deficiency anemia is the type of anemia caused by iron depletion. LBW = Lean body weight in kg. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Consult your pharmacist or local waste disposal company. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron.