I have now started to put on weight, which, for years, I have battled with, but have decided not to worry about it and go with the flow. I feel at least I am doing something. Doctor gave me antibiotics for ear and throat infection not working at all. I understood the reason to be careful about the sore throat was because the Carbimazole can reduce your immune system and the sore throat could be a sign of this. My appetite has always been good but eating everything in site and feeling starving within 5 minutes was definately odd. I am now on 10mg carbimazole a day and feel much better. Have got another blood test on Monday. Sore throat, mouth ulcers, fever, bruising, uneasiness, jaundice, nausea, loss of taste, headache, joint pain and hair loss. © Patient Platform Limited. Anyway I have totally forgot about getting bloods done to check if carbimazole is cause of sore throat. ... Sore throat, fever, or mouth ulcers. They may also switch you to an alternative drug to do the same job. How should you take it? Unfortunately I gained about 1.5 stones until I went on meds. Try our Symptom Checker Got any other symptoms? I don't want to even think about that! A less common but more serious side effect is a sudden drop in your white blood cell count (agranulocytosis), which can make you very vulnerable to infections. Manufacturer advises of the importance of recognising bone marrow suppression induced by carbimazole and the need to stop treatment promptly. This sheet tells you what to do in the event of you experiencing symptoms which might indicate these effects. 13 years ago, I have had severe trembling, palpitations and weight loss, severe headaches and blurred vision for over 7 months. The dose of propyl thiouracil is 10 times that of carbimazole, so if you are just taking 5mg of carbimazole, you will switch to 50mg of PTU. respect of any healthcare matters. If the patient attends with a fever, flu like symptoms, mouth ulcers or a sore throat, this may indicate the development of neutropaenia. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Registered in England and Wales. However, very rarely, a patient reacts to the drug with a sudden loss of white blood cells (‘neutrophils’) from the blood. All anyone said was, "In time!" The most frustrating thing for me is not being in control. Patient does not provide medical advice, diagnosis or treatment. Carbimazole given with a potent CYP3A4 inhibitor is predicted to increase the exposure to propiverine. Our clinical information is certified to meet NHS England's Information Standard.Read more. Call your doctor right away if you have any signs of infection like fever, chills, flu-like signs, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or a wound that will not heal. Tell your doctor immediately: Headache. Can anyone tell me before I rang my GP. Propylthiouracil. A white blood cell count should be performed if there is any clinical evidence of infection. My advice is to give it a few more weeks and things will improve and you will gain some of your weight back. Carbimazole is used to treat hyperthyroidism. … I hope you get your results soon and that they find the cause to the problem . Carbimazole may be used alone or together with other treatments for hyperthyroidism. Hi I been taking this tablets for 6 weeks now (3 5mg 3 times a day). I reply to all of you as well as Kaye, I too am taking Carbimazole, have been taking them for around 2 and a half years I think?! Although I was told that had I not been as fit, when I was rushed to hospital (heart rate 220 and in Resus for 9 hours) it could have been fatal. I've seen the endo on Thurs and my levels are coming down but after getting more angry/weepy, less muscle strength and other stuff I was begining to feel like it would never end. If you develop any of these symptoms, please stop your medication immediately and bring this … But as time has gone on, I occasionally get sore throats, I have been to the Docs, who have  usually looked into my throat and said something like " Oh, it's O.K nothing to do with the Carbimazole"....on the odd occasion I have had to have an extra blood test because of it, but, they have always come back O.K. If the white cell count is low, please contact the endocrine team immediately. Hypersensitivity to the antithyroid drugs 2. I am now on block and replace as the Carbimazole took my thyroid levels below average so am on Thyroxine to bring them to normal levels. Take care, I know things will get better. Severe but rare side effects of taking Carbimazole: Carbimazole can very rarely be associated with a condition called agranulocyrtosis (low neutrophil count) which can have symptoms including sore throat, bruising or bleeding, mouth ulcers, fever, malaise. The antithyroid drugs include carbimazole, methimazole, and propylthiouracil (PTU). as being in breach of those terms. There are alternative AT drugs so it's might just be a question of switching to another : Obviously currently with Covid restrictions it's confusing for you but either way it needs sorting sooner rather than later. This is where the white blood cells are affected so that they do not fight infection properly - one of the symptoms can be a sore throat. Manufacturer advises adjust starting dose. I lose track of time I'm afraid! Severity of interaction: Moderate Evidence for interaction: Theoretical. Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T 3 and T 4 (thyroxine). My last 4 weeks have been hell although I have felt better in myself over the last few days. May enhance the effect of anticoagulants. Have had 3 weeks off work already and still not right. I've been waiting for someone to say that it does get better and I'm not going mad. Antihistamines may be given for associated pruritus if necessary. Take carbimazole regularly as directed with a glass of water. Used in the management of thyroid diseases., drugs | specialties | general news | education ... (e.g. Carbimazole should only be administered if hyperthyroidism has been confirmed by laboratory tests. How to take carbimazole tablets Before you start this treatment, read the manufacturer's printed information leaflet from inside your pack. Registered number: 10004395 Registered office: Fulford Grange, Micklefield Lane, Rawdon, Leeds, LS19 6BA. If the patient has had both carbimazole and PTU, or you are concerned about the patient or require further information, please contact the endocrinolgy doctor on call. You have been started on tablets to control your overactive thyroid gland. That pressure can quickly spread from the back of … Carbimazole/PTU treatment and sore mouth I throat. I also got a blood test referral to go for went into get it but the queue was massive so walked out had to get to work. I agree with you Kaye, I used to be more active than I am now, ALWAYS tired, and can't do much at all, how frustrating this is!! No use telling us not to worry when we've been warned about side effects now is there?! Some side effects may need immediate medical help. There is a rare serious side effect from carbimazole called Agranulocytosis. Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine). The suppression of the bone marrow is often temporary with the bone marrow recovering after 1-2 week. Well, here I am, still waiting for my voice to get back to what it was! No one REALLY tells you what will happen to you with an overactive thyroid! I'm self employed so I've been able to take a back seat and my husband has taken over everything except phone calls and emails. Carbimazole(Camazol) generic Neo -Mercazole is a pro-drug, prescribed for hyperthyroidism. ... chills, sore throat or generally feeling unwell, or easy or unusual bruising or bleeding. ... Customers taking other prescription medicines such as carbimazole should be referred to the pharmacist immediately. If they are taking carbimazole, please prescribe propylthiouracil (PTU) in place of the carbimazole - the dose of PTU is 10 times the dose of carbimazole (for example 20mg carbimazole = 200mg PTU). I read in the leaflet that came with it if you got sore throat STOP taking the tablets and see your doctor, what I would like to know is how bad must the sore throat be to stop taking the tablets? It does feel like a lifetime just existing though and thats difficult to get my head around, no wonder I want to kill someone sometimes!!! Patient should be asked to report symptoms and signs suggestive of infection, especially sore throat. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. But, we must carry on the best we can, I know it's very hard, but, at least on here, we have each other, and we KNOW what we're talking about, and do not tell each other, NOT TO WORRY!! Symptoms of liver problems including: yellow skin or eyes, itching, dark urine, pale bowel motions, abdominal pain. Hair … Therefore, if you develop a sore throat, mouth ulcers, rash or an unexplained fever, stop taking the tablets immediately and have your white cell count checked urgently either through your GP or by going to your local Accident and Emergency department. In such patients, white blood cell counts should be performed … I have no control over my body anymore, it controls me! A white blood cell count should be performed if there is any clinical evidence of infection. well, at least, not in the same way some of the 'proffesionals' do!! Carbimazole may cause any of the following side effects: headache, nausea, stomach discomfort, rash and hair loss. Sore Throat Or Mouth Ulcers After Taking Carbimazole? Yep, almost jumped for joy....whoopsy, 6 weeks later when I had a blood test, yep, you've guessed it, thyroid had returned to overactive, and back on the tablets I went, and am still taking them! I hate it....howong b4 u started gaining the weight back? sore throat, bruising or bleeding, mouth ulcers, fever, malaise). Pyrimethamine. These tablets are very safe, but do occasionally cause the side effects of a rash or reduced blood cell count. PTU doses should be divided and given two or three times a day (for example 100mg bd). That's exactly how I feel. The crying will stop, the sicky feeling goes and you will sleep through the night again. We want the forums to be a useful resource for our users but it is important to remember that the forums are Coming to this Forum helped me a lot and I want to tell you to hang in there because you will feel better but it does take a long time. Spotty Rash And Sore Throat Carbimazole Sore Throat strep throat is a bacterial infection of throat nasal cavity and its surrounding regions. Older people. I do a lot of singing in church, and when I had to start on the tablet, my singing voice was non-existant!! Hyperthyroidism :: Carbimazole Causing Sore Throat? Side Effects Recommended action Reduced number of blood cells that fight infections or help your blood to clot - symptoms include: fever, chills, sore throat or generally feeling unwell, or easy or unusual bruising or bleeding Angioedema, a serious allergic reaction with symptoms that may include swollen tongue, lips, face or throat Lung problems, with symptoms that include shortness of breath or a cough Kidney problems, with symptoms that include a reduction in the amount of urine passed, fluid retention and blood in the urine. The... Take this medicine exactly as your doctor tells you to. The dose of propyl thiouracil is 10 times that of carbimazole, so if you are just taking 5mg of carbimazole, you will switch to 50mg of PTU. Foods for cold and flu symptoms; Fighting a fever with food; Help headaches with Soft foods will be easier to swallow with a sore throat and some soft foods like hot soup Hot lemon and honey tea may relieve coughing. Your GP may prescribe you with an anti histamine drug to control the itching or rash if necessary. presents as a severe sore throat, mouth ulcers, fever. People say I look healthier and I do feel so much better. Drug Interactions . Sore Throat :: Swollen Tonsils, Lump In Throat, Clear Mucus, Sore, Headache; Sore Throat :: Sore Throat, Overall Ill Feeling No Diagnosis; Ankylosing Spondylitis :: Flare Ups Of Sore Throat And Sore Oesophagus; Carbimazole :: Stopping Carbimazole - Started To Gain Weight This patient is taking carbimazole/PTU for their thyroid condition. Contra-indications of Carbimazole 1. YOU MUST REST whenever possible. Carbimazole during pregnancy and lactation Carbimazole can be used in pregnancy. I am very sad about this, I know this must sound quite trivial when we have lots of other symtoms, but, to me, it IS important for me to keep on singing! You have been started on carbimazole treatment for an overactive thyroid. He apologised that this has been missed. When I was put on Carbimazole I was told to go straight to A & E if I developed a sore throat. May increase the … It is not predicted from routine WBC measurements and should be suspected in patients on high doses presenting with a sore throat, mouth ulcer or any serious infection. If this is not possible, please see your GP or go to the emergency department. I have put the weight back on without trying, which is a pain, and have been advised not to go back to exercising just yet, although I am walking for half an hour each day. The sore throat was at times very severe but this did not indicate anything adverse for me. not moderated or reviewed by doctors and so you should not rely on opinions or advice given by other users in Thank you lovely, I was told I'd put it all back on & more lol....I'm also on hormone therapy now & that also makes u gain weight..... glad to hear u are doing well & feel well now. Patients should always be warned about the onset of sore throats, bruising or bleeding, mouth ulcers, fever and malaise and should be instructed to stop the drug and to seek medical advice immediately. appropriate medical assistance immediately. Believe me, rest has helped me get better. Reporting of side effects If you develop any of these symptoms, please stop your medication immediately and bring this letter to hospital immediately to have a blood test. I have been going through themail same thing only I was misdiagnosed. I no longer have palpitations, hair loss or surges in my metabolism causing hot sweats. One of the more serious side effects of carbimazole, a treatment for an overactive thyroid gland, is bone marrow … Upgrade to Patient Pro Medical Professional? This is possibly why dr has asked you to stop just to rule this out. I do have OA too, so, combine the two, I'VE HAD IT!! My levels are on the way down but I know I could start gaining weight any time soon. My GP'so failed to notice the signs of an over active thyroid all this time (so I was informed by my own GP whom I can never get in to see). Always speak to your doctor before acting and in cases of emergency seek along with all my muscles which became just like jelly! Do not start taking your medication again until you have been told that your blood test is satisfactory. The only thing that helps where that's concerned is that I wouldn't need to consume the amounts I have, and I'd be healthy enough to actually work it off!!! mainly because I wasn't told why to stop taking the tablet if I got a sore throat! The risk of agranulocytosis is lower with carbimazole than with propylthiouracil. Sore throat, fever, or mouth ulcers If you develop any of these symptoms, please stop your medication immediately and bring this letter to hospital immediately to have a blood test. Investigations confirmed a leucopenia and neutropenia. The info about resting is good as I normally go all guns blazing if I get a good day and it's left to my mum to tell me to rest (I'm 38 yrs old mind you!). All rights reserved. G-CSF was used as an adjunctive therapy with discontinuation of carbimazole, barrier nursing and a broad-spectrum antibiotic regimen to treat her neutropenic sepsis. I am waiting to see an endocrinologist. This is a very safe treatment that has been used for over 50 years. I've now lost about a third of that just down to the fact I'm eating more normally (obviously I'm not exercising yet!). If possible, please let the endocrinology doctor on call know that you are coming, as this may speed things up for you. and Privacy Policy and steps will be taken to remove posts identified Life for me feels so much better - which is such a relief because I felt so ill. 31 users are following. Obstruction in the trachea. Agranulocytosis is dangerous and affects about 0.3 in 1000 patients (1). I wish you all well, and keep your chins up....I'll keep both of mine up folks!! Patients with low white blood cells may develop a sore throat, mouth ulcers, rash, or fever. Carbimazole is used to reduce the amount of hormone made by your thyroid gland. Both carbimazole and propylthiouracil can increase the risk of myelosuppression. Carbimazole: Belongs to the class of sulfur-containing imidazole derivative agents. These tablets are very safe, but do occasionally cause the side effects of a rash or reduced blood cell count. A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole. All that hard work in the gym ruined! B4 u started gaining the weight back if you develop any of these symptoms, please contact endocrine! By carbimazole and propylthiouracil ( PTU ) or thiamazole a white blood cell count bad health that. Nursing and a half now suppression induced by carbimazole and propylthiouracil ( PTU ) infection, especially sore throat strep! Was at times very severe but this has stopped me in my metabolism Causing sweats! Ulcers, fever or mouth ulcers, read the manufacturer 's printed leaflet! Blood tested a few more weeks and things will improve and you will gain of! 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